Doctors Have Successfully Transplanted Treated Human Liver Into Machine – List of Codes

Scientists are working on new ways to maintain the viability of donated organs without resorting to extreme cold.

The liver is the second most frequently transplanted organ after the kidney. Photo: Shutterstock.

The transplant Organ harvesting is a very complicated medical procedure. The organ must be compatible with the recipientand the process also involves moving a living organ from donor to recipient and maintaining the organ in good working order until surgery.

The traditional method of moving organs to transplant is to store them at very low temperatures. However, this process has a time limit and can damage organic tissues.

For this reason, scientists are working on new ways to maintain the viability of donated organs without resorting to extreme cold.

One such group is the Liver4Life research team in Zurich, Switzerland, which used an infusion machine to keep a human liver alive for three days. Doctors then implanted the liver in a human patient, who now, a year after the procedure, is doing well.

Traditional organ transplant

According to the United Network for Organ Sharing, more than 41,000 transplants took place in 2021 in the United States. The liver it is the second most frequently transplanted organ after the kidney.

Every 9 minutes, someone is placed on a waiting list for transplant of organs. Although UNOS reports that the percentage of people donating their organs has increased, there is still a shortage of available organs. And 17 people on average die every day while waiting for a transplant of organs.

Different organs can be kept in cold storage for different lengths of time before their tissues begin to break down. For instance, the cold ischemia time of a heart is 4-6 hours, while a kidney lasts much longer, 24-36 hours. The liver It can be kept cold for 8-12 hours.

As it concerns liver, to research Previous studies show that a prolonged period of cold ischemia can impair the liver transplant. Others to research found that cold ischemia time prolongs the patient’s hospital stay after transplant.

What is an infusion machine?

Researchers are studying infusion machines as an alternative method of storing organs outside the body. The machine mimics the functions of the body’s heart and lungs, pumping blood and oxygen to the organ.

Additionally, medical professionals deliver a cocktail of hormones and nutrients to the organ, much like the intestines and pancreas would receive in the body.

Prof. Pierre-Alain Clavien, director of the visceral surgery department and Transplant from the University Hospital of Zurich (USZ) Switzerland, and lead author of this study, He said the infusion machine preserves a liver transplant, not for a few hours, but for several days.

“It makes it possible to transform liver transplant from an emergency operation to an elective operation,” he explained. “Secondly, this extended time on the infusion machine allows for in-depth treatment of the liver before the transplantwhich until now was not possible.

“There are many ways to use the infusion machine,” Professor Clavien added. “The main objective is to treat patients by providing them with a good graft or even a segment of liver regenerated for autotransplantation after treatment. [También es] The possibility offered by this platform to carry out toxicological studies without the need to test in humans is very interesting”.

To look forward

As for the next steps for this new technology, Professor Clavien said his team is currently planning a multicenter clinical trial for the transplant grafts of liver long-term storage in your infusion set.

He also thinks that infusion machine technology could one day be used for other organs. “This technology is theoretically suitable for all transplanted organs today, although some adjustments to the circuit would need to be made,” Clavien explained.

“In particular, we are also interested in renal and uterine perfusion, the feasibility of which has already been demonstrated in our preclinical experiments,” he added.

MNT also spoke with Dr. Robert S. Brown, Jr., Vincent Astor Professor Emeritus of Medicine and Chief of the Division of Gastroenterology and hepatology from Weill Cornell Medicine, about this study.

Said mechanical organ perfusion has enormous potential increase the number of organs available for transplant:

“These long durations really offer the possibility of taking an organ that would work, but nobody has confidence that it works, and it increases the confidence that it would work. And a future ability to maybe even manipulate the organ with drugs or […] future gene therapy to then remove non-transplantable organs and make them transplantable.

“It has the potential to have a huge impact on the patient in terms of increase organ access by making more organs available for transplantation and increasing organ quality by taking previously untransplantable organs and turning them into transplantable or marginally transplantable organs and turning them into good organs,” Prof Brown added.

“I would see this as an exciting proof of concept that needs further validation, but if validated, it would be a big step forward.”

Source consulted here.

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